Note: This course is not available for the current semester.
Course No: 36.580; Last Offered: Summer 2015;
This course begins with a review of basic molecular genetics, followed by a discussion of the human genome project, including the application of its technology to the management of genetic diseases. Laboratory techniques used to analyze pre- and postnatal tissue samples is described, including RFLP-Southern blot technology, various forms of PCR, VNTR assessment, and gene expression analysis by microchip arrays. Cloning and stem cell analysis follows, including the ethical, legal, and social issues surrounding these areas. Cancer genetics and cytogenesis is presented, with emphasis on molecular changes that lead to the onset of cancer. Genetic treatments for cancer are reviewed. Gene therapy is detailed, including the historical perspective, gene therapy vectors and their mode of action, and the newest methods for treating genetic disorders at the DNA level. Structural and functional genomics follows, centering around the creation of pharmaceuticals solely based on the genetic basis of diseases. This is followed by a detailed section on epigenetics and its application to diagnosis and prediction of disease phenotypes. GWAS (Genome Wide Association Studies) is detailed as it applies to diagnosis in both individuals and entire populations. The course ends with a discussion of the human proteome project, and the human transcriptome project, including goals and objectives, current progress, and the storage of data in complex bioinformatic databases.
Contact the Advising Center at 978-934-2474 or Continuing_Education@uml.edu
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